The product, marketed as a “SIRT6 Activator,” is the latest offering from the health‑research organisation DoNotAge.org, whose founder Alan Graves and scientific advisory board member Dr Vera Gorbunova say the formula is designed to support the body’s natural DNA‑repair mechanisms.
Sirtuin 6 is one of seven protein enzymes that regulate cellular health, metabolism, stress response and ageing. According to Gorbunova, the enzyme’s activity declines with age, slowing cellular repair and impairing energy production.
Research by Gorbunova over the past two decades on long‑lived mammals such as naked mole‑rats and bowhead whales has shown a correlation between higher SIRT6 activity and extended lifespans, a finding the DoNotAge team says underpins their supplement’s rationale.
The activator’s key ingredient is a specific type of fucoidan – a polysaccharide found in brown seaweed – which the company claims can “activate Sirtuin 6, supporting DNA repair and a more youthful epigenome.” Graves emphasizes that the supplement does not add SIRT6 itself but aims to enhance the function of the enzyme already present in the body.
Developing the product reportedly required up to six months of seaweed harvesting, batch testing and refinement, as most fucoidan extracts either lack activity or can be harmful, according to Graves. Testing is conducted in Gorbunova’s laboratory in New York.
DoNotAge.org positions the supplement for long‑term use, suggesting that its benefits may be subtle and accrue over years rather than being immediately perceptible. The company cites observations of high SIRT6 activity in centenarians as supportive evidence, though independent clinical validation has not been presented.
While the launch adds to a growing market of longevity‑focused nutraceuticals that include NAD+ and NMN, experts caution that the health claims remain unverified by regulatory bodies and that consumers should consider the lack of peer‑reviewed efficacy data.