The announcement, posted by Southern Command, cited "confirmed intelligence" that the targeted vessel was engaged in drug‑trafficking operations, and stated that the strike resulted in four fatalities.
The operation is the latest in a campaign that began last year under the Trump administration, aimed at what officials label "narco‑terrorists" operating in the Caribbean and Eastern Pacific maritime zones.
The September 19 strike follows a similar attack ten days earlier in the Caribbean that the U.S. military said killed three individuals.
According to Southern Command figures, strikes on vessels in the Caribbean and Eastern Pacific since the campaign's inception have killed more than 220 people.
The U.S. has not released the name or exact location of the vessel, and independent verification of the casualties has not been provided.